ICD-11 Codes
for 2A00.00 - Glioblastoma of brain

Teodor Jurukovski January 1, 1970

Fact checked by: Teodor Jurukovski

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Understanding glioblastoma of brain

Glioblastoma of brain, classified under ICD-11 code 2A00.00, is a highly aggressive malignant astrocytic tumour designated as World Health Organization grade IV. It is the most common primary malignant brain tumour in adults and is associated with rapid progression and poor prognosis.

Although glioblastoma can occur at any age, it is most frequently diagnosed between 45 and 70 years of age. These tumours most commonly arise in the cerebral hemispheres but may develop in any region of the central nervous system. Their infiltrative growth pattern makes complete surgical removal difficult.

Common symptoms and clinical presentation

Symptoms of glioblastoma of brain often develop quickly and may initially be nonspecific. Clinical features are influenced by tumour location, associated brain oedema, and increased intracranial pressure.

As the tumour enlarges, symptoms may progress rapidly and can include declining consciousness or acute neurological deterioration.

Causes and risk factors

The exact cause of most glioblastoma of brain cases remains unclear. Tumour development is believed to result from complex genetic and molecular alterations within astrocytic cells.

Diagnosis of glioblastoma of brain

Diagnosis involves correlation of clinical findings, neuroimaging, and pathological confirmation. Imaging studies are essential for assessing tumour extent and guiding surgical planning.

Magnetic resonance imaging is the preferred modality due to its ability to define tumour margins, necrosis, and surrounding oedema. Computed tomography may be used in emergency settings. Definitive diagnosis requires biopsy or surgical resection, allowing histopathological grading and molecular testing, which are critical for treatment planning and prognosis.

Treatment and management considerations

Management of glioblastoma of brain is complex due to its aggressive behaviour and infiltrative growth. Treatment is typically multimodal and aims to prolong survival, preserve neurological function, and manage symptoms.

Emerging therapies such as tumour treating fields and targeted molecular treatments are under active investigation and may be used in selected cases.

Synonyms and alternative terms

Glioblastoma of brain is commonly referred to by several alternative clinical terms. Recognition of these synonyms supports accurate documentation and continuity of care.

Documentation and ICD-11 coding considerations

Accurate documentation is essential for clinical care, billing, and epidemiological reporting. Glioblastoma of brain should be coded using ICD-11 code 2A00.00. This code is billable and reportable when supported by appropriate diagnostic evidence.

Clinical notes should clearly document imaging findings, histopathological confirmation, and tumour grade. ICD-11 also allows postcoordination with additional codes to specify tumour location, laterality, or molecular features where relevant.

Are glioblastoma of brain ICD codes billable

Yes. ICD-11 code 2A00.00 is a billable diagnosis code. When supported by imaging and pathological confirmation, it may be used for reimbursement, clinical reporting, and healthcare analytics. Use of the most specific available code improves data accuracy and supports appropriate clinical and financial workflows.