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Diseases of the immune system is a chapter in ICD-11 that includes conditions resulting from dysfunctions of the body’s immune defenses, leading to impaired protection against infections or inappropriate immune responses. These disorders may involve immune deficiency, immune dysregulation, or hypersensitivity reactions, and can be congenital or acquired. As a result, affected individuals may experience recurrent infections, autoimmune manifestations, chronic inflammation, or allergic responses.
This chapter encompasses a broad range of immune-related conditions, including primary and secondary immunodeficiencies, autoimmune diseases, autoinflammatory syndromes, and disorders related to immune system overactivity. Proper classification within this chapter supports accurate diagnosis, targeted treatment, and long-term management, while also aiding research, surveillance, and the development of therapies aimed at restoring or modulating immune function.
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This chapter includes disorders characterized by impaired, excessive, or abnormal immune responses.
It includes primary and secondary immunodeficiencies, autoimmune diseases, autoinflammatory disorders, and hypersensitivity reactions.
Immune disorders reflect dysfunction of the immune system itself, whereas infections are caused by external pathogens.
Yes. Both inherited immune disorders and acquired immune dysfunctions are included.
ICD-11 aligns classification with advances in immunology and clinical diagnostics.
It supports accurate diagnosis, targeted therapies, research, and public health reporting.
