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ICD Hub / Diseases of the blood or blood-forming organs (D50–D89) / 3A01.3 - Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
ICD-11

ICD-11 Codes
for 3A01.3 - Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
Teodor Jurukovski January 1, 1970
Fact checked by: Teodor Jurukovski
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This condition, identified by ICD-11 code `3A01.3`, is also commonly referred to as pernicious anaemia, particularly when it stems from an autoimmune attack on the stomach's parietal cells. Other related terms include congenital intrinsic factor deficiency, gastric intrinsic factor deficiency, and hereditary juvenile megaloblastic anaemia due to intrinsic factor deficiency. These terms highlight the core issue: the body's inability to produce or utilise intrinsic factor, which is essential for vitamin B12 absorption.

Factors Contributing to Vitamin B12 Deficiency Anaemia

The primary cause of Vitamin B12 deficiency anaemia due to intrinsic factor deficiency (ICD-11 code `3A01.3`) is a lack of intrinsic factor, a protein produced by stomach parietal cells. This can occur due to autoimmune conditions like pernicious anaemia, where the body attacks its own parietal cells. Congenital intrinsic factor deficiency is a rare genetic disorder present from birth. Other factors that can impair vitamin B12 absorption or lead to deficiency, though not directly related to intrinsic factor deficiency itself, include certain digestive diseases (like Crohn's or celiac disease), gastrointestinal surgeries (such as gastric bypass), and chronic alcohol use disorder. Individuals with a family history of these conditions or those following strict vegan diets may also be at increased risk for general vitamin B12 deficiency, though intrinsic factor deficiency has specific causes.

Recognising the Signs of Vitamin B12 Deficiency Anaemia

Patients experiencing Vitamin B12 deficiency anaemia due to intrinsic factor deficiency may present with a range of symptoms. Common signs include extreme tiredness and lack of energy. Neurological manifestations are also significant and can involve numbness or tingling sensations in the hands and feet, difficulties with memory or concentration, and problems with balance or walking. Physical symptoms might include a sore or red tongue, mouth ulcers, and pale skin. Psychological changes such as irritability or depression can also occur. The severity and type of symptoms can vary greatly among individuals.

How Vitamin B12 Deficiency Anaemia is Diagnosed

Diagnosing Vitamin B12 deficiency anaemia due to intrinsic factor deficiency (ICD-11 code `3A01.3`) typically involves a combination of medical history, physical examination, and laboratory tests. Blood tests are crucial and may include a complete blood count (CBC) to assess red blood cell size and number, serum vitamin B12 levels, and folate levels. Further investigations might include tests for methylmalonic acid (MMA) and homocysteine, which are often elevated in B12 deficiency. To pinpoint the cause related to intrinsic factor, specific tests like checking for anti-intrinsic factor antibodies can help diagnose pernicious anaemia. For congenital forms, genetic testing may be considered.

Strategies for Managing Vitamin B12 Deficiency Anaemia

The management of Vitamin B12 deficiency anaemia due to intrinsic factor deficiency focuses on replenishing vitamin B12 levels. Since the deficiency is linked to impaired absorption due to a lack of intrinsic factor, treatment often involves vitamin B12 injections (parenteral administration), which bypass the need for intrinsic factor. Hydroxocobalamin is frequently preferred over cyanocobalamin. In some cases, very high doses of oral vitamin B12 may be effective if intestinal receptors can be saturated. Long-term therapy is often necessary, especially for conditions like pernicious anaemia. Patients should seek medical advice for appropriate treatment plans.

Understanding Vitamin B12 Deficiency Anaemia Due to Intrinsic Factor Deficiency

Vitamin B12 deficiency anaemia due to intrinsic factor deficiency, coded under ICD-11 `3A01.3`, is a condition where the body's inability to absorb vitamin B12 properly leads to a lack of healthy red blood cells. This malabsorption is specifically linked to a deficiency or dysfunction of intrinsic factor, a vital protein produced in the stomach. Without adequate intrinsic factor, vitamin B12 cannot be effectively absorbed in the small intestine, leading to deficiency. This can result in megaloblastic anaemia, characterised by abnormally large red blood cells, and can also cause significant neurological and psychological symptoms if left untreated.

Frequently asked questions

What is the ICD-11 code for Vitamin B12 deficiency anaemia due to intrinsic factor deficiency?
The ICD-11 code for Vitamin B12 deficiency anaemia due to intrinsic factor deficiency is 3A01.3.
How is Vitamin B12 deficiency anaemia due to intrinsic factor deficiency classified in ICD-11?
In ICD-11, Vitamin B12 deficiency anaemia due to intrinsic factor deficiency (3A01.3) is classified under Megaloblastic anaemia due to vitamin B12 deficiency.
What are the specific ICD-11 categories related to Vitamin B12 deficiency anaemia due to intrinsic factor deficiency?
ICD-11 includes specific categories such as Pernicious anaemia (3A01.30) and Vitamin B12 deficiency anaemia due to intrinsic factor deficiency, unspecified (3A01.3Z), under the broader classification of 3A01.3.
What is the ICD-11 classification for Pernicious anaemia?
Pernicious anaemia is classified in ICD-11 as 3A01.30, which is a specific type of Vitamin B12 deficiency anaemia due to intrinsic factor deficiency.
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