ICD-11 Codes
for 4A00.3 - Immunodeficiency with natural-killer cell deficiency

Teodor Jurukovski January 1, 1970

Fact checked by: Teodor Jurukovski

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Understanding Immunodeficiency with Natural-Killer Cell Deficiency

Immunodeficiency with natural-killer cell deficiency (ICD-11 code 4A00.3) is a condition affecting the immune system. Natural killer (NK) cells are a crucial part of the innate immune defence, playing a role in combating viral infections and certain types of cancer. A deficiency in these cells or their function impairs the body's ability to fight off these threats. This condition falls under the category of primary immunodeficiencies, meaning it is typically congenital or genetic in origin.

Understanding the Origins of NK Cell Deficiency

Immunodeficiency with natural-killer cell deficiency (ICD-11 code 4A00.3) is primarily a congenital condition. This means it is typically caused by genetic mutations inherited from parents, leading to the abnormal development or function of natural killer cells from birth. While specific gene defects are still being identified, these genetic factors are the main risk for developing this type of primary immunodeficiency.

Alternative Names for Immunodeficiency with Natural-Killer Cell Deficiency

This condition may also be known by several other terms, including:

• NK cell deficiency
• Natural killer cell deficiency
• Primary immunodeficiency with natural-killer cell deficiency

When to Consult a Healthcare Professional

Individuals experiencing recurrent or severe infections, or those with a known family history of immune system disorders, should consult a healthcare professional. If you suspect an issue with your immune system, particularly concerning susceptibility to infections, seeking timely medical advice is important for proper evaluation and management of conditions like Immunodeficiency with natural-killer cell deficiency (ICD-11 code 4A00.3).

Diagnosing Immunodeficiency with Natural-Killer Cell Deficiency

The diagnosis of Immunodeficiency with natural-killer cell deficiency (ICD-11 code 4A00.3) involves a comprehensive evaluation by healthcare professionals. This typically includes detailed medical history, physical examinations, and specific laboratory tests. Blood tests are crucial for assessing the number and function of natural killer (NK) cells. Advanced immunological assays may be used to identify specific defects in NK cell activity or to pinpoint underlying genetic causes.

Coding and Documenting Immunodeficiency with Natural-Killer Cell Deficiency

For accurate medical record-keeping and billing, Immunodeficiency with natural-killer cell deficiency is classified under the ICD-11 code 4A00.3. This code falls within Chapter 04, Diseases of the immune system, specifically under Primary immunodeficiencies. Proper documentation by healthcare providers is essential to assign the correct code, which may be relevant for billing purposes, including diagnostic related groups (DRGs) such as 814 - Reticuloendothelial & Immunity Disorders W Mcc, 815 - Reticuloendothelial & Immunity Disorders W Cc, and 816 - Reticuloendothelial & Immunity Disorders W/o Cc/mcc.

Managing NK Cell Deficiency

Management strategies for Immunodeficiency with natural-killer cell deficiency (ICD-11 code 4A00.3) focus on preventing and treating infections, as well as addressing the underlying immune defect. This can involve a range of approaches, from prophylactic measures to more advanced therapeutic interventions. Ongoing research continues to explore innovative treatment options and a deeper understanding of the biology of NK cells offers potential for future advancements in patient care.